The first one-volume guide to sources of contamination in pharmaceuticals and medical devices Most books dealing with contaminants in medicinal products often focus on analytical methods for detecting nonspecific impurities. Key to the work of the pharmaceutical chemist, this unique reference helps identify the sources of contamination in medicinal and pharmaceutical products and medical devices. Divided into three parts, Sources of Contamination in Medicinal Products and Medical Devices covers chemical, microbiological, and physical (particulate matter) contamination, including those originating from sterilization procedures. As compelling as a medical documentary, the book sheds light on how impurities and contaminants can enter the human body transported via a specific product or treatment. Focusing on only those medicinal products and medical devices that may lead to exposure to contaminants harmful to human health, the book offers a comprehensive, systematic look at the entire universe of medical contamination: Chemical contaminants including residual solvents, catalyst residuals, and genotoxic impurities in active pharmaceutical ingredients (APIs) Diagnostic imaging agents (i.e., radiopharmaceuticals and contrast agents) Microbiological and endotoxin contamination involving single and multiple dose products, medical devices, and biofilms Contamination from sterilization procedures, residuals from radiation sterilization, ionizing radiation on packaging materials and medical devices Medicinal gases and volatile anesthetics Biopharmaceuticals including recombinant DNA technology products Extractables and leachables from containers made of glass, plastics, and metal Each section of the book contains information on what contaminants could be expected in a particular product, and how they were generated and reached that product. With up-to-date regulatory guidelines for determining contamination, as well as methods for assessing, quantifying, avoiding and removing contaminants, Sources of Contamination in Medicinal Products and Medical Devices is essential to fully understanding the specific threats that undermine the safety of medicines and medical devices.
This book covers the ecological activities of microbes in the biosphere with an emphasis on microbial interactions within their environments and communities In thirteen concise and timely chapters, Microbial Ecology presents a broad overview of this rapidly growing field, explaining the basic principles in an easy-to-follow manner. Using an integrative approach, it comprehensively covers traditional issues in ecology as well as cutting-edge content at the intersection of ecology, microbiology, environmental science and engineering, and molecular biology. Examining the microbial characteristics that enable microbes to grow in different environments, the book provides insights into relevant methodologies for characterization of microorganisms in the environment. The authors draw upon their extensive experience in teaching microbiology to address the latest hot-button topics in the field, such as: Ecology of microorganisms in natural and engineered environments Advances in molecular-based understanding of microbial phylogeny and interactions Microbially driven biogeochemical processes and interactions among microbial populations and communities Microbial activities in extreme or unusual environments Ecological studies pertaining to animal, plant, and insect microbiology Microbial processes and interactions associated with environmental pollution Designed for use in teaching, Microbial Ecology offers numerous special features to aid both students and instructors, including: Information boxes that highlight key microbial ecology issues «Microbial Spotlights» that focus on how prominent microbial ecologists became interested in microbial ecology Examples that illustrate the role of bacterial interaction with humans Exercises to promote critical thinking Selected reading lists Chapter summaries and review questions for class discussion Various microbial interactions and community structures are presented through examples and illustrations. Also included are mini case studies that address activities of microorganisms in specific environments, as well as a glossary and key words. All these features make this an ideal textbook for graduate or upper-level undergraduate students in biology, microbiology, ecology, or environmental science. It also serves as a highly useful reference for scientists and environmental professionals. PowerPoint slides of figures from the book are available for download at: ftp://ftp.wiley.com/public/sci_tech_med/microbial_ecology
Diploma in Dental Nursing, Level 3 is the new edition of the must-have study companion for trainee dental nurses preparing for the City & Guilds Level 3 Diploma in Dental Nursing (formerly NVQ). The book offers comprehensive support on the units assessed by portfolio – from first aid and health and safety to specific chairside support procedures – as well as the four areas of the course tested by multiple choice questions: infection control, oral health assessment, dental radiography and oral health management. This third edition of an established revision text has been substantially revised and restructured in line with the new qualification and reflects changes in the regulations and legislature affecting dentistry and dental workplaces, all of which have an effect on the daily role and working life of the dental nurse. It will be an invaluable guide for dental nurse trainees, qualified dental nurses and course providers. – Expanded and revised, with extensive coverage of the fifteen Diploma units – In full colour throughout with over 400 illustrations – Companion website with downloadable glossary and MCQs for revision and self-assessment
The premiere two-volume reference on revelations from studying complex microbial communities in many distinct habitats Metagenomics is an emerging field that has changed the way microbiologists study microorganisms. It involves the genomic analysis of microorganisms by extraction and cloning of DNA from a group of microorganisms, or the direct use of the purified DNA or RNA for sequencing, which allows scientists to bypass the usual protocol of isolating and culturing individual microbial species. This method is now used in laboratories across the globe to study microorganism diversity and for isolating novel medical and industrial compounds. Handbook of Molecular Microbial Ecology is the first comprehensive two-volume reference to cover unculturable microorganisms in a large variety of habitats, which could not previously have been analyzed without metagenomic methodology. It features review articles as well as a large number of case studies, based largely on original publications and written by international experts. This first volume, Metagenomics and Complementary Approaches, covers such topics as: Background information on DNA reassociation and use of 16 rRNA and other DNA fingerprinting approaches Species designation in microbiology Metagenomics: Introduction to the basic tools with examples Consortia and databases Bioinformatics Computer-assisted analysis Complementary approaches—microarrays, metatranscriptomics, metaproteomics, metabolomics, and single cell analysis A special feature of this volume is the highlighting of the databases and computer programs used in each study; they are listed along with their sites in order to facilitate the computer-assisted analysis of the vast amount of data generated by metagenomic studies. Handbook of Molecular Microbial Ecology I is an invaluable reference for researchers in metagenomics, microbiology, and environmental microbiology; those working on the Human Microbiome Project; microbial geneticists; molecular microbial ecologists; and professionals in molecular microbiology and bioinformatics.
The premiere two-volume reference on revelations from studying complex microbial communities in many distinct habitats Metagenomics is an emerging field that has changed the way microbiologists study microorganisms. It involves the genomic analysis of microorganisms by extraction and cloning of DNA from a group of microorganisms, or the direct use of the purified DNA or RNA for sequencing, which allows scientists to bypass the usual protocol of isolating and culturing individual microbial species. This method is now used in laboratories across the globe to study microorganism diversity and for isolating novel medical and industrial compounds. Handbook of Molecular Microbial Ecology is the first comprehensive two-volume reference to cover unculturable microorganisms in a large variety of habitats, which could not previously have been analyzed without metagenomic methodology. It features review articles as well as a large number of case studies, based largely on original publications and written by international experts. This second volume, Metagenomics in Different Habitats, covers such topics as: Viral genomes Metagenomics studies in a variety of habitats, including marine environments and lakes, soil, and human and animal digestive tracts Other habitats, including those involving microbiome diversity in human saliva and functional intestinal metagenomics; diversity of archaea in terrestrial hot springs; and microbial communities living at the surface of building stones Biodegradation Biocatalysts and natural products A special feature of this book is the highlighting of the databases and computer programs used in each study; they are listed along with their sites in order to facilitate the computer-assisted analysis of the vast amount of data generated by metagenomic studies. Such studies in a variety of habitats are described here, which present a large number of different system-dependent approaches in greatly differing habitats. Handbook of Molecular Microbial Ecology II is an invaluable reference for researchers in metagenomics, microbial ecology, microbiology, and environmental microbiology; those working on the Human Microbiome Project; microbial geneticists; and professionals in molecular microbiology and bioinformatics.
The Human Microbiota offers a comprehensive review of all human-associated microbial niches in a single volume, focusing on what modern tools in molecular microbiology are revealing about human microbiota, and how specific microbial communities can be associated with either beneficial effects or diseases. An excellent resource for microbiologists, physicians, infectious disease specialists, and others in the field, the book describes the latest research findings and evaluates the most innovative research approaches and technologies. Perspectives from pioneers in human microbial ecology are provided throughout.
This book presents a comprehensive and substantial overview of the emerging field of food safety engineering, bringing together in one volume the four essential components of food safety: the fundamentals of microbial growth food safety detection techniques microbial inactivation techniques food safety management systems Written by a team of highly active international experts with both academic and professional credentials, the book is divided into five parts. Part I details the principles of food safety including microbial growth and modelling. Part II addresses novel and rapid food safety detection methods. Parts III and IV look at various traditional and novel thermal and non-thermal processing techniques for microbial inactivation. Part V concludes the book with an overview of the major international food safety management systems such as GMP, SSOP, HACCP and ISO22000.
Sedation is a procedure that makes use of sedative medications to produce a relaxed experience for the patient. The central nervous system (CNS) is affected through the use of drugs, including tranquilizers and anxiolytics, that can be administered to the patient in several ways. Sedation dentistry has several benefits, both for dentists and patients. For patients, it can mean freedom from anxiety or fear during dental procedures. In cases where a patient has not been able to undergo dental treatment for many years because of this fear, sedation dentistry allows him to have several years' worth of dental treatment in just a few sessions. For dentists, sedation dentistry facilitates the easy performance of dental procedures. Patients are likely to be more cooperative under the relaxing effects of sedation. Treatments can also be quicker, because a number of procedures can be performed in a single session. Dental nurses play a vital role in assisting the dentist in the routine sedation of patients. In acknowledgement of this, the NEBDN run a post-qualification certificate in Dental Sedation Nursing that provides the dental nurse with the theoretical knowledge and practical skills required to carry out their role safely and competently. The ‘Basic Guide to Dental Sedation Nursing' is a must have book for all dental nurses seeking to develop their knowledge and understanding of this core area of clinical practice. Written in a clear and accessible style, chapters reflect the Certificate in Dental Sedation Nursing syllabus with chapters on such key topics as legal aspects, anatomy, equipment, patient assessment, types of sedation, medical emergencies and resuscitation. Illustrated in full colour throughout Handy format for easy reference and portability Evidence-based
Basic Guide to Dental Instruments provides a working inventory of dental instrumentation in common use in dental surgeries. A clear photograph of each instrument is included, and described according to name, usage, any relevant features and varieties. Each section is dedicated to a specific discipline or division of dentistry. Complete set-ups have been included at the end of most sections for various procedures. The coverage reflects instrumentation and accessory items used in general dental practice, routine hospital dental procedures and selected specialist settings. The author adopts a flexible approach which recognises that some instruments are multi-functional, and their names and usage can vary across dental surgeries. This approach, coupled with the range of instruments covered, makes the book an ideal 'portable' resource across general practice, hospital and a range of specialist settings. The book also highlights instruments which can be easily confused. In addition to detailing the classic sets of dental instruments, the importance of instrument care and sterilisation regimes is acknowledged. This second edition contains an expanded chapter on instruments used in conjunction with dental implants, and illustrations have been updated throughout. FEATURES Best-selling title Brand new chapter on instruments used in dental implantology Expanded chapter on dental burs Illustrations revised throughout
Dental Management of Sleep Disorders focuses on the dentist’s role in treating patients with sleep problems, chiefly sleep disordered breathing and bruxism. A practical clinical book, Dental Management of Sleep Disorders highlights the background to these problems, discusses the dentist’s role in their diagnosis and treatment, and outlines clinical strategies and guidance. The book features a full discussion of the use of appliances, an overview of current treatment modalities, and investigates the relationship of sleep disorders to dental and orofacial causes.
"Welcome" is a two level beginner's course for children learning English. The workbook accompanies "Welcome 1: Coursebook". "Welcome 1: Workbook" includes: 14 units corresponding to the units of the coursebook; four-page units corresponding to the units in the coursebook; five sections (vocabulary, grammar, communication, listening, reading and writing); pictures in full colour and stickers; hand puppets.
Fully revised and updated to reflect changes in clinical practice, legislation and regulation, this groundbreaking textbook intertwines the subjects of dental hygiene and dental therapy to provide a comprehensive resource for students of these courses, as well as those studying new degree programmes in oral health science. The Clinical Textbook of Dental Hygiene and Therapy is designed as a dedicated companion text for these disciplines and should enable students to streamline their primary reading. Following course developments and an expansion in the remits of both hygienists and therapists, this book is written not only for students, but also as a revision aid for those already in practice. Interactive questions on a companion website allow the reader to test their knowledge and understanding. The opening section of the book is dedicated to relevant oral sciences: anatomy; histology; embryology; oral medicine and pathology. The clinical section contains fourteen chapters which provide coverage of the core syllabus for dental hygiene and therapy. The final section is dedicated to primary dental care services and law, ethics and professionalism. FEATURES • Provides unique combined coverage of the subjects of dental hygiene and dental therapy • Emphasises the clinical domain and reflects role expansion • Highly illustrated in full colour throughout • Includes expert contributions from dental hygienists, therapists, and dentists • Dedicated companion website at www.wiley.com/go/noble/dentalhygiene
Endorsed by Cambridge International Examinations, Cambridge IGCSE Economics covers the Cambridge syllabus (0455). The book draws extensively on real world examples to explore economic concepts, theories and issues. Each of the 52 units deals with a specific topic in a lucid and pertinent manner. A number of activities, based on examples from around the world, are designed to facilitate students' easy understanding of the contents. There is a range of questions both at the end of units and at the end of each of the eight sections to assess students' progress in the subject.