Normal wound healing involves a complex and dynamic but superbly orchestrated series of events leading to the repair of injured tissues. Acute wounds normally heal in a very orderly and efficient manner characterized by four distinct, but overlapping phases: hemostasis, inflammation, proliferation and remodelling. Specific biological markers characterize healing of acute wounds. Likewise, unique biologic markers also characterize pathologic responses resulting in fibrosis and chronic non-healing ulcers. As we continue to develop new information about the unique biological markers associated with normal and pathologic wound healing responses, the better prepared we will be to develop new strategies to treat these costly clinical problems. In addition, understanding this basic biological information will allow wound care specialists greater insight into the importance of how their skills can impact the healing response.
Wound healing is a natural curative reaction to tissue injury involves the interaction of a complex flow of cellular events that generates resurfacing, reconstitution, and restoration of the tensile strength of injured tissue. Diabetic patients are suffering from delayed wound healing due to abnormality in the progression of normal wound healing phases. Lymphocytes are playing central role in wound healing and its augmented apoptosis due to hyperglycemia leads to delayed wound healing. Prolonged delayed wound healing revolves into chronic wounds which finally ended by amputation. We showed that oxidative stress is playing one of the major role in attenuation of lymphocyte apoptosis in diabetic patients. Better understanding of factors involved in lymphocyte apoptosis may be important to open new traditions for the management of wound healing.
The plant Saussurea lappa (costus) was used in the traditional medicine to treat wounds. Although, there are no scientific reports on wound healing activity of Saussurea lappa in the literature, the present study was suggested to evaluate its scientific validity. This investigation was undertaken to determine the efficacy of Saussurea lappa on wound healing. This study used the roots of Saussurea lappa to evaluate wound healing activity using tissue culture model as in vitro and excision wound model in rats as in vivo. The in vitro results showed that Saussurea lappa increase proliferation of fibroblasts and thus accelerate wound healing. Application of Saussurea lappa to a wound performed in rats showed that the healing process was faster than control group with out appearance of any infection.As conclusion, Saussurea lappa may be reveal as safe and effective topical medicine for accelerating wound healing.
Wound healing is a complex and dynamic process with the wound environment changing with the changing health status of the individual. The knowledge of the physiology of the normal wound healing trajectory through he phases of homeostasis, inflammation granulation and maturation provides a framework for an understandingly of the basic principles of wound healing. Through this understanding the health came professionals can develop the skills required to care for a wound and the body can be assisted in the complex task of tissue repair. A chronic wound should prompt the health came professional to begin a search for unresolved underlying causes. Healing a chronic wound requires care that is patient centered, holistic interdisciplinary, cost effective and evidence based.
This book provides a study on wound healing and anti inflammatory activity of rhizomes of kali haldi. Kali haldi is ayurvedic plant used traditionaly in india for treating fever, epilepsi, tootheche, fever, vometing, bronchitis etc. In present study ethanolic extract of rhizomes of kali haldi evaluated for wound healing and anti inflammatory activity in wistar rats. wound healing activity is proved by incision and excision wound healing model and anti inflammatory activity is proved by carrageenan induced paw oedema in rats.
Chronic and non-healing skin wounds represent a significant clinical, economic and social problem in both developing and developed countries. There are few effective treatments. The lack of relevant animal models to gain insights into the mechanism of human wound healing and, therefore, to identify new and more effective therapeutic targets remains a major challenge. While pig wound healing is considered closest to human wound healing, standardized pig models with demonstrated validity for new therapeutic studies are needed. This report is a systematic evaluation and establishment of both a normal and a diabetic pig wound healing model. We show similar histological changes taking place in diabetic pig and human skin and demonstrate a strong correlation between the duration of diabetic conditions and the length of delay in wound healing. We demonstrate the effectiveness of recombinant Hsp90? protein, to promote both acute and diabetic wound healing in these pig models. More importantly, we have narrowed down the minimum therapeutic entity of secreted Hsp90? to a 27 amino acid peptide. Also, two amino acids of Hsp90? are shown to be important to the migration of skin cells in vitro.
The present study was aimed to investigate the possible effects of polyherbal formulation containing extracts of Ageratum conyzoides, Ficus religiosa, Curcuma longa and Tamarindus indica, on wound healing process through excision wound models in mice. The groups treated with Polyherbal formulation (ointment) showed increase in the rate of wound contraction and decrease in the period of epithelization in animals which may be attributed to its wound healing activity. In these studies, the only rational explanation for the accelerated wound healing is the antibacterial effect and also the synergetic effect of constituents present in polyhebral formulation.
Wound healing still remains a major problem in surgical practice, because of our inability to accelerate the process of healing. Abscesses are an extremely common problem in surgical clinics of India. Incision and draining along with systemic and local antibiotics are necessary elements of treatment of these abscess cavities. However some cavities are reluctant and slow to heal and lead to prolonged morbidity. Although it has been known for about 50 years that phenytoin can accelerates wound healing, very few authentic documentation of utility of phenytoin in wound healing as a standard procedure is available. Therefore the present study is conducted to evaluate the role of phenytoin in healing of abscess cavities.
Wound healing of injured skin and other tissues is fundamental for survival. Platelets are a rich source of potential wound-healing promoting factors. Four different human acute wound models and a wide array of clinical and laboratory wound healing assessment tools and parameters were to used to investigate the effect of an autologous platelet- rich fibrin; collagen synthesis and deposition in the ePTFE tube wound, breaking strength of small human incision wounds, epithelialization of the split-thickness skin graft donor site wound, epithelialization of the transplanted meshed autograft on a surgically revised leg ulcer, recovery of skin physiological properties over 1 year using non-invasive techniques (erythema, pigmentation, TEWL). The thesis is organized into an introduction to the wound healing process with emphasis on collagen metabolism and the very potent profibrotic growth factor TGF-b1, followed by a short literature review on the clinical use of different platelet-rich preparations. Specific studies are presented in detail, experimental methods are explained and results presented and discussed.
This study reveals the negative impact of diabetes mellitus on wound healing, both in experimental and clinical settings. Achyranthes aspera have been used in the traditional medicine for treatment of diabetes, wound healing, and many other complications. In the present investigation wound healing potential of ethanolic extract of Achyranthes aspera has been evaluated in normal treated and hyperglycemic rats. EEAA contains saponins, alkaloids, and flavonoids. Two weeks repeated dose treatment of EEAA, Reduced serum glucose level and restored body weight Produced antihyperglycemic effect. Reduced clotting time and haemoglobin content Showed faster wound contraction rate.Improved RBCs and WBCs count. Normalize the oxygen flow capacity and colour index. showed improvement in biochemical parameter estimation. Histopath study showed increased epithelisation of wound granulating tissue and protective effect on architecture of ? cells. SDS- PAGE analysis of wound tissue shows different proteins expression compared to normal animals. Thus it indicates that Achyranthes aspera possesses potential as a wound healing agent and also have antidiabetic activity.
The wound healing is complex process and brings immense challenges to researchers. The nanofiber provides an alternative approach for wound healing treatment. Human tissues and organs exhibit nanofiber structures. Nanofibers are produced by electrospinning technique and showed promising approach in management of wound care applications. This book will be a handy reference when you opt for nanofibers study. The present book describes about nanofibers, biopolymers, methods for production of nanofibers and achievements of nanofibers in wound care management.
The mechanism of tissue healing is a complex biological process that involves a perfect and coordinated cascade of cellular and molecular events promoting tissue reconstitution. This process arises as a response of the tissue to injuries induced by trauma or by surgical procedures.The process of wound healing is characterized by four phases that overlap and present a characteristic profile: Hemostasis, inflammatory phase, proliferative phase and remodeling phase. Despite some recent advances in the understanding of these basic processes, wound healing disorders continue to cause diseases and even death. The application of phyto-therapeutic agents has also shown to be highly effective in the healing of wounds and burns.
The Care of Wounds addresses all aspects of holistic wound management. The fourth edition of this successful clinical text continues to reflect current research and evidence-based practice, while incorporating the considerable developments which have occurred in wound care practice since the previous edition. It includes chapters on the physiology of wound healing, general principles of wound management, wound management products, and the management of patients with both acute and chronic wounds. The title is an essential read for all nurses and healthcare professionals working in the field of tissue viability and wound healing. Comprehensive and clinically-oriented Examines best practice in wound management Incorporates national and international clinical guidelines where applicable Superbly illustrated with full colour throughout
Ayurveda is the ancient health science of the India. Ayurveda has described the management of wound in detail. Many herbal formulations are being successfully used for wound healing since historical times. Medicated oils like Vranashodhanahara Tail and Doorvadi Tail are the examples of such formulations. This book is about the pharmaceutical standardization of Vranashodhanahara Tail and Doorvadi Tail; and the experimental study of their wound healing activity on albino rats. Today various research facilities and analytical techniques are easily available. On this background re-validation of the pharmacological activities and establishment of therapeutic utility of these medicines will establish the faith of physicians and researchers in Indian system of medicine.