Cancer Stem Cells covers a wide range of topics in cancer stem cell biology, including the functional characteristics of cancer stem cells and how they're generated, where they are localized, the means by which cancer stem cells can be targeted, and how cancer stem cells can be reprogrammed back to normal tissue stem cells. Each chapter begins with a brief historical note and concept summary, followed by a description of the latest basic or clinical advance associated with the topic. Cancer Stem Cells builds systematically from coverage of the basic research stage to an advanced research level, from clinical relevance to therapeutic potential, and will be a valuable resource for professionals in the fields of cancer research and stem cell biology.
This research focuses on gene therapy as well as immunotherapy to target the breast cancer stem cells in breast cancer treatment. Breast cancer stem cells were isolated and proliferated from malignant breast tumors. About gene therapy, we used knockdown gene therapy to suppress the CD44 expression. CD44 holds an important role in stemness maintenance of breast cancer stem cells. CD44 down regulation makes breast cancer stem cells sensitize to anti-tumor drug (doxorubicin). So that combinatorial therapy of CD44 down-regulation and doxorubicin strongly suppressed the tumor growth in NOD/SCID mice. In another way, we used dendritic cell therapy to target breast cancer stem cells. Dendritic cells were loaded with breast cancer stem cells derived antigens. The results also showed that dendritic cell vaccination inhibits the cancer development in mice models.
Because the concept and discoveries of cancer stem cells are relatively new, scientists and researchers need an introduction to this dynamic area. Cancer Stem Cells presents a consolidated account of the research done to date and recent progresses in the studies of cancer stem cells. Such a presentation facilitates a better understanding of and draws attention to stem cell and cancer biology – two fields that enhance, move, and evolve into each other continuously. It provides an informative study in designing approaches to apply stem cell principles to cancer biology while offering an overview of the challenges in developing combination stem and cancer biology targets for therapeutics. This book serves as a primer for new researchers in the field of cancer biology.
The focus of this book is on cancer stem cells (CSC, also known as cancer initiating cells), a stimulating topic in cancer research. P-cadherin, an adhesion molecule overexpressed at the surface of breast cancer cells, may help identify the CSCs from basal-like carcinomas, a particular aggressive subtype of breast cancer. This constitutes an attractive target for a malignancy that has such a negative impact worldwide.
Stem Cell Therapeutics for Cancer covers the application of stem cells in various cancers, with an emphasis on the aspects of these strategies that are critical to the success of future stem cell-based therapies for cancer. Topics covered in the book include stem cell sources, tumor specificity, targeted therapeutics, visualizing the stem cell, and therapeutic agent pharmacokinetics. Each chapter contains a brief introduction to the cancer, followed by an exploration of how engineered stem cells have been utilized to cure the disease in mouse models and in early phase clinical trials. Comprises of sections on stem cell therapy in brain cancers, lung cancers, breast cancers, as well as stem cells in combination with other therapies Focuses on the practical applications of using stem cells as gene delivery agents to treat cancer Includes coverage of cutting-edge molecular imaging techniques in stem cell therapeutics for a variety of tumour types
Cell and Molecular Biology and Imaging of Stem Cells features original and review articles written by experts who have made significant contributions to stem cell biology and imaging. Chapters cover a broad spectrum of aspects of the field, including Stem cells from the Amniotic Fluid and Placenta, Biomaterials as Artificial Niches for Pluripotent Stem Cell Engineering, Low-Intensity Ultrasound in Stem Cells and Tissue Engineering, Mammalian Neo-Oogenesis from Ovarian Stem Cells, Oct4-EGFP Transgenic Pigs as a New Tool for Visualization of Pluripotent and Reprogrammed Cells, Regulation of Adult Intestinal Stem Cells, Stem Cell Therapy for Veterinary Orthopedic Lesions, Sex Steroid Combinations in Regenerative Medicine for Brain and Heart Diseases, Hair Follicle Stem Cells, The Potential of Using Induced Pluripotent Stem Cells in Skin Diseases, Mitochondrial Differentiation in Early Embryo Cells and Pluripotent Stem Cells, and The Role of Centrosomes in Cancer Stem Cell Functions. Cell and Molecular Biology and Imaging of Stem Cells addresses a wide variety of cell and molecular topics in unprecedented detail, and is a must-read for graduate students and academic and industry professionals in the expanding field of stem cell biology. Reviews new imaging tools and markers for cell and molecular imaging in stem cell biology. Covers novel aspects of stem cell imaging in reproductive biology and stem cell niches Includes chapters on the developing area of centrosome biology as it applies to embryonic and adult stem differentiation
Cancer stem cells (CSC) have been detected in breast tumours and in breast cancer cell lines; they are a subpopulation of tumour cells with tumour initiating capacity, which self-renew and give rise to progeny that constitute the tumour bulk. It has been suggested that CSCs are major drivers of relapse after treatment because they are relatively resistant to drug- and radiation-induced cell death. Analysis of breast cancer stem cells has a major significance in the field of cancer therapy. From a therapeutic perspective, it is important to focus on the CSC population most responsible for tumour initiation, metastasis and relapse. But it is not currently clear which characteristics most define the highly tumorigenic population. Regarding this, my project focused on two main characteristics of CSCs: expression of pluripotency factors such as OCT4, and slow cycling properties using existing breast cancer cell lines MCF7 and MDA-MB-231 that are known to contain a CSC population.Also, I attempted to leverage the marine bioproducts expertise of the Medical Biotechnology Department, and the Flinders Centre for Marine Bioproducts Development to screen for novel sponge-derived chemicals.
Stem cells are one of the wonders of biology. Some of the reasons for using these cells include the possibility to save their proliferation during cell cycle and their ability to differentiate into various types of mature cells, whereas normal cell can only give rise to its kind. Stem cells are divided into two with respect to their source viz embryonic stem cells and adult stem cells. Considering the limitations of working with embryonic stem cells, there is a growing interest among researchers to focus their studies on adult stem cells. Adult stem cells are found in many organs and tissues, but the important factor is the number of cells in each tissue is very limited. Accordingly, the present study investigates the cultivation of adult stem cells in dental pulp as a potential rich source of these cells. Dental pulp stem cells (DPSC) do not require general anesthesia during extraction as compared to bone marrow stem cells. They also have a very high proliferation rate when cultured and their properties are most closely related to the embryonic stem cells.
The use of stem cells for research, whether from children, adults, aborted fetuses, or embryos, must be done under conditions of the most rigorous integrity for several reasons. The use of adult stem cell requires the same conditions as those required in the case of tissue donation, based on respect for the integrity of the human body and the free and informed consent of the donor. The use of foetal tissues to derive stem cells requires, besides informed consent, that no abortion is induced for the purpose of obtaining the tissues and that the termination timing and the way it is carried out are not influenced by this retrieval. This book is a try to usher light on path of ethical requirements for carrying out stem cell research in cancer therapy.
Cancer is the uncontrolled growth of abnormal cells in the body. Cancerous cells are also called malignant cells. Symptoms of cancer depend on the type and location of the cancer.To kill cancerous cells, it is necessary to specifically kill them and leave the normal good cells. Microsspheres is a recent technology in the treatment of cancerous cells specifically because of their micro sized nature. Application of Microspheres in the treatment of cancer leading to lesser side effect to normal cells is the latest trend in formulation technology.
It has been established that human dental pulp and periodontal ligament contain a population of mesenchymal stem cells (MSCs). However, the phenotypic analysis in terms of putative stem cell markers expressed by these stem cell populations is incomplete. It is relevant to understand whether stem cells derived from closely related tissues are programmed differently. This book therefore, provides an insight into the phenotypes of dental pulp stem cells (DPSCs) and periodontal ligament stem cells (PDLSCs). Both the stem cells express embryonic stem (ES) cell markers. Differences were observed in expression of stemness-related markers. DPSCs displayed increased percentages of SSEA4, CD13 and CD166 and decreased CD9 expression compared to PDLSCs. Both stem cells express common MSC markers, different levels of expression suggests there might be more than one stem cell population existing within these tissues which differ in their embryonic status, and DPSCs are a more primitive stem cell population in comparison to PDLSCs. This analysis should shed some light into the nature of stem cells from dental tissues and help researchers utilize these stem cells for regenerative medicine.
Stem Cells Are Boon In Medical Sciences. Stem Cell Research is pursued in hope Of achieving major Medical & Dental breakthrough. This book positions stem cell research & its use in Periodontology as an emerging discipline . The authors summarize the current research on stem cells in periodontics & outline the basic concepts of stem cells, its role in medicine & dentistry with emphasis in periodontics with its benefits & speculate on their clinical utility in these fields.
Beginning with Stem cell definition and classification, a good narrative synthesis of all stem cells has been included. Almost all aspects of Stem Cells from Exfoliated Deciduous teeth has been covered. Extensive literature survey has been carried out on uses of SHED Cells. Isolation protocols, SHED cell banking have been elaborately explained. Recent studies using SHED Cells for dental tissue regeneration has been explained. Role of SHED Cells in Regenerative Endodontic procedures have been focused.
Легкая гелевая маска создана на основе последних достижений косметологии, в ее состав входит экстракт культуры растительных фитоклеток швейцарской яблони, аналог низкомолекулярной гиалуроновой кислоты и огромный комплекс дополнительных ингредиентов, направленных на мощную регенерацию кожи. Эта уникальная формула восстанавливает кожу на клеточном уровне, избавляет от всех признаков хронологического, гормонального и фотостарения. Маска обладает высокой anti-age-активностью и существенно уменьшает глубину морщин, интенсивно гидратирует кожу, защищает ее от агрессивного воздействия окружающей среды и УФ, повышает тургор и эластичность, улучшает оптические свойства кожи. Активно нейтрализует свободные радикалы, препятствует разрушению коллагена и эластина, активизирует процессы его последующего восстановления. Регулярное применение маски замедляет раннее образование морщин, восстанавливает баланс увлажнённости и микрорельеф кожи. СПОСОБ ПРИМЕНЕНИЯ: Нанести маску тонким слоем на очищенную кожу лица и шеи, рекомендуется нанесение на область губ и глаз, оставить на 15-20 минут, после чего смыть водой. Применять 2 раза в неделю.